Lanthio Pharma receives Dutch Government loan of up to €3.6 million to develop novel therapy for lung fibrosis

May 21, 2014 / 7:30 am, CEST

Lanthio Pharma B.V., the biopharmaceutical company focused on discovering and developing lanthipeptides, announced today that it has been awarded an Innovation Credit loan of up to €3.6 million by Dutch Government agency RVO. The Innovation Credit loan will support the development of LP2, an innovative lanthipeptide for treatment of Idiopathic Pulmonary Fibrosis.

LP2 is the first peptide-based drug to selectively activate the Angiotensin type 2 (AT2) receptor of the Renin Angiotensin System (RAS). The natural role of the AT2 receptor is to protect damaged tissue against inflammation and fibrosis. Once safety and efficacy of LP2 is established in Idiopathic Pulmonary Fibrosis patients, application of LP2 could be extended to many other forms of fibrosis, including renal fibrosis, heart fibrosis and liver fibrosis.

The Innovation Credit loan is made available by Dutch Government agency RVO to stimulate innovative drug development in The Netherlands. The loan is risk bearing and will be matched by Lanthio Pharma’s investors. The loan covers up to 35% of development costs through to completion of Phase II human Proof of Concept trials.

Bart Wuurman, CEO of Lanthio Pharma commented: “We are very pleased with this support by the Dutch Government to help us develop our fibrosis drug. We are keen to show that LP2 is effective against Idiopathic Pulmonary Fibrosis, a life threatening disease for which effective treatments are not yet available.”

Media contact:                                      Company contact:
80th Atom                                                Lanthio Pharma
Adam Michael                                          Bart Wuurman, CEO
+44 1223 511338                                     +31 64 662 3735
+44 777 588 1813                                    +31 50 305 0240

Innovation Credit contact:

Kees van Hoeven
+31 88 602 5401



About Lanthio Pharma (
Lanthio Pharma is a privately held drug discovery company that applies its proprietary lanthionine-peptide technology to the discovery of novel peptide therapeutics with longer half-life and high receptor selectivity. Lanthio Pharma has already discovered several lanthipeptides for a number of GPCR targets, which is a focus area of the company.

Constrained peptides like lanthipeptides are an emerging compound class which offers the potential to address many types of target and disease categories, currently beyond reach for therapeutic proteins or small molecules. Lanthio Pharma is building a pipeline of therapeutic lanthipeptide drugs against diseases of high medical interest, like fibrosis, cardiovascular diseases, multiple sclerosis and cancer.

The technology of Lanthio Pharma includes a proprietary bacterial display library capability, which allows construction of focused or randomized libraries of lanthipeptides that can be screened against disease targets of interest. MorphoSys AG has obtained the rights to commercialize Lanthio’s technology.

Lanthio Pharma is funded by Inkef Capital, BioGeneration Ventures, MorphoSys and RUG Holding.

About Idiopathic Pulmonary Fibrosis (IPF)
IPF is an orphan, life-threatening lung disease characterized by fibrosis and scarring of the lung tissue. Replacement of normal lung tissue by scar tissue results in restriction in the ability of the lungs to transfer oxygen from inhaled air into the bloodstream. It is estimated that IPF affects approximately 130,000 patients in the US and approximately 76,000 patients in Europe. There is no curative therapy.

About Innovation Credit (Innovatiekrediet)
Innovation Credit is a risk bearing loan from the Ministry of Economic Affairs to Dutch companies for the technical or clinical development of a new product, process or service. (

The Innovation Credit facility is managed by the Rijksdienst voor Ondernemend Nederland (RVO), which encourages entrepreneurs in sustainable, agrarian, innovative and international business. It helps with grants, finding business partners, know-how and compliance with laws and regulations. RVO is part of the Ministry of Economic Affairs.

About INKEF Capital
INKEF Capital provides long term capital and business advice to starting entrepreneurs in the Netherlands. From the very early stages of a high tech venture, INKEF Capital supports entrepreneurs building their ideas into a successful business. Providing seed capital to turn a great idea into a company or providing growth capital to give a running start-up the next push, INKEF Capital is the partner for the long haul.

About BioGeneration Ventures
BioGeneration Ventures manages funds that are actively investing venture capital in the next generation of successful life sciences companies, active in healthcare therapeutics, medical devices, diagnostics and novel food applications, in the Netherlands, Belgium and Germany.

About MorphoSys
MorphoSys AG (FSE: MOR; Standard Segment, TecDAX) is today one of the world’s leading biotechnology companies. From a pure antibody platform enterprise MorpoSys has matured into a renowned biopharmaceutical company with a rich pipeline of future therapeutic antibody products and a sustainable dual therapeutic business model.

In addition to therapeutic antibodies, MorphoSys strives to complement its technology platform by securing access to new markets and molecule classes. The technology alliance and equity investment in Lanthio Pharma, which was signed in 2012, is part of this Innovation Capital Initiative. Within the framework of their commercial agreement, MorphoSys and Lanthio Pharma will combine their technologies to develop high-quality and diverse lanthipeptide libraries.

About RUG Holding
RUG Holding initiates and supports companies based on knowledge and expertise from the University of Groningen. The Holding participates in spin off ventures in which entrepreneurial co-workers of the University are founders and/or essential inventors.